Cajun Chicken Alfredo Fettuccine

Featured in: Classic Comfort Foods

This dish combines tender chicken breasts seasoned with Cajun spices, cooked to golden perfection, and served over perfectly al dente fettuccine. The sauce blends Velveeta cheese with butter, garlic, heavy cream, and Parmesan, producing a creamy, smooth coating with a gentle kick of heat from cayenne pepper. Finished with fresh parsley and optional extra Parmesan, it balances spice and creaminess for a hearty, satisfying meal. Cooking time is about 40 minutes total, making it a straightforward option for a flavorful American Cajun-inspired main.

Updated on Sat, 22 Nov 2025 16:18:00 GMT
Tender sliced Cajun chicken tops creamy Cajun Chicken Alfredo Fettuccine Pasta with vibrant parsley garnish. Save to Pinterest
Tender sliced Cajun chicken tops creamy Cajun Chicken Alfredo Fettuccine Pasta with vibrant parsley garnish. | krispyrecipes.com

A creamy, spicy pasta dish featuring tender Cajun-seasoned chicken, rich Velveeta cheese sauce, and perfectly cooked fettuccine—comfort food with a Southern twist.

I love how this Cajun Chicken Alfredo Fettuccine always brings warmth and smiles to our family dinners.

Ingredients

  • Chicken: 2 large boneless skinless chicken breasts, 1 ½ tablespoons Cajun seasoning, 1 tablespoon olive oil
  • Pasta: 12 oz (340 g) fettuccine pasta
  • Sauce: 2 tablespoons unsalted butter, 2 cloves garlic minced, 1 cup (240 ml) heavy cream, 8 oz (225 g) Velveeta cheese cubed, ½ cup (50 g) grated Parmesan cheese, ½ teaspoon black pepper, ¼ teaspoon cayenne pepper (optional for extra heat), Salt to taste
  • Garnish: 2 tablespoons fresh parsley chopped, Extra grated Parmesan cheese (optional)

Instructions

Step 1:
Bring a large pot of salted water to a boil. Cook the fettuccine according to package instructions until al dente. Drain and set aside reserving ½ cup pasta water.
Step 2:
While the pasta cooks, pat chicken breasts dry. Rub both sides with Cajun seasoning.
Step 3:
In a large skillet, heat olive oil over medium-high heat. Add chicken and cook 5 6 minutes per side or until golden and cooked through (internal temperature 165°F/74°C). Remove chicken let rest 5 minutes then slice thinly.
Step 4:
In the same skillet, reduce heat to medium. Add butter and garlic sauté 1 minute until fragrant.
Step 5:
Stir in heavy cream and bring to a gentle simmer. Add Velveeta cubes stirring often until melted and smooth.
Step 6:
Add Parmesan cheese, black pepper, and cayenne pepper (if using). Stir until fully combined and creamy. If sauce is too thick add reserved pasta water a little at a time.
Step 7:
Toss cooked fettuccine in the sauce until well coated.
Step 8:
Divide pasta among plates. Top with sliced Cajun chicken. Garnish with parsley and extra Parmesan if desired.
Beautiful plated dish of steamy Cajun Chicken Alfredo Fettuccine Pasta, showcasing a luscious Velveeta cheese sauce. Save to Pinterest
Beautiful plated dish of steamy Cajun Chicken Alfredo Fettuccine Pasta, showcasing a luscious Velveeta cheese sauce. | krispyrecipes.com

This meal always reminds me of cozy family nights where everyone gathers around the table sharing stories and laughter.

Notes

Adjust Cajun seasoning for more or less heat. Substitute rotisserie chicken for a quicker version. Add sautéed bell peppers or mushrooms for extra flavor and color. Pairs well with a crisp green salad and a chilled Chardonnay.

Required Tools

Large pot, large skillet, knife and cutting board, tongs or pasta fork, measuring cups and spoons

Allergen Information

Contains milk/dairy (Velveeta Parmesan cream butter). Contains wheat (fettuccine). Contains chicken. Those with allergies should check ingredient labels for hidden allergens.

Imagine the rich, spicy aroma of this Cajun Chicken Alfredo Fettuccine Pasta, perfect comfort food, ready to serve! Save to Pinterest
Imagine the rich, spicy aroma of this Cajun Chicken Alfredo Fettuccine Pasta, perfect comfort food, ready to serve! | krispyrecipes.com

This Cajun Chicken Alfredo is sure to become a family favorite with its creamy texture and bold flavors.

Common Recipe Questions

What type of chicken is best for this dish?

Boneless, skinless chicken breasts work best as they cook evenly and absorb Cajun seasoning well.

Can I use another type of cheese in place of Velveeta?

Yes, creamy cheeses like cheddar or American cheese can be substituted, though texture and flavor may vary slightly.

How do I make the sauce smoother if it’s too thick?

Adding reserved pasta water a little at a time helps thin the sauce while keeping it creamy and well-coated.

Is the dish spicy, and can I adjust heat levels?

The Cajun seasoning and optional cayenne provide moderate heat; you can reduce or omit cayenne for milder flavor.

What side dishes pair well with this pasta?

Fresh green salads or steamed vegetables complement the rich and spicy elements of this dish beautifully.

Cajun Chicken Alfredo Fettuccine

Spicy Cajun chicken paired with creamy Velveeta sauce and fettuccine in a comforting Southern style.

Prep Duration
15 minutes
Cooking Duration
25 minutes
Overall Time
40 minutes
Created by Mia Harper

Recipe Type Classic Comfort Foods

Skill Level Easy

Cuisine Type American (Cajun-inspired)

Total Portions 4 Serving Size

Dietary Considerations None specified

What You’ll Need

Chicken

01 2 large boneless, skinless chicken breasts
02 1 ½ tablespoons Cajun seasoning
03 1 tablespoon olive oil

Pasta

01 12 ounces fettuccine pasta

Sauce

01 2 tablespoons unsalted butter
02 2 cloves garlic, minced
03 1 cup heavy cream
04 8 ounces Velveeta cheese, cubed
05 ½ cup grated Parmesan cheese
06 ½ teaspoon black pepper
07 ¼ teaspoon cayenne pepper (optional)
08 Salt, to taste

Garnish

01 2 tablespoons fresh parsley, chopped
02 Extra grated Parmesan cheese (optional)

How to Make It

Step 01

Cook pasta: Bring a large pot of salted water to a boil. Cook fettuccine following package directions until al dente. Drain, reserving ½ cup pasta water, then set aside.

Step 02

Prepare chicken: Pat chicken breasts dry and rub both sides evenly with Cajun seasoning.

Step 03

Sear chicken: Heat olive oil in a large skillet over medium-high heat. Cook chicken 5 to 6 minutes per side until golden and internal temperature reaches 165°F (74°C). Remove and rest 5 minutes before slicing thinly.

Step 04

Start sauce: Lower heat to medium. Add butter and minced garlic to the skillet; sauté for 1 minute until fragrant.

Step 05

Simmer cream and cheese: Pour in heavy cream and bring to a gentle simmer. Add Velveeta cubes gradually, stirring continuously until melted and smooth.

Step 06

Season sauce: Incorporate grated Parmesan, black pepper, cayenne (if using), and salt. Stir until fully combined and creamy. Thin sauce with reserved pasta water as needed.

Step 07

Combine pasta and sauce: Toss cooked fettuccine in the cheese sauce until evenly coated.

Step 08

Plate and garnish: Serve pasta on plates, top with sliced Cajun chicken, then garnish with fresh parsley and optional extra Parmesan.

Tools You’ll Need

  • Large pot
  • Large skillet
  • Knife and cutting board
  • Tongs or pasta fork
  • Measuring cups and spoons

Possible Allergens

Double-check each ingredient for allergens and consult an expert if you're unsure.
  • Contains dairy (Velveeta, Parmesan, cream, butter).
  • Contains wheat (fettuccine).
  • Contains poultry (chicken).
  • Individuals with allergies should verify ingredient labels for hidden allergens.

Nutritional Information (per serving)

This data is for informational purposes and shouldn't replace professional advice.
  • Calorie Count: 670
  • Total Fat: 32 grams
  • Total Carbohydrates: 57 grams
  • Protein Content: 41 grams